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brucei but not the human UBA1. This is particularly the case for TbUBA1b, the protein with the best job in viability. Whereas the space in TbUBA1a appears restricted across the gatekeeper residue, this isn't the case for TbUBA1b due to presence of Y628 (Fig. 6C). Also, the pocket of TbUBA1b lined by G630, S631, Y660, T657 is longer than that of hU

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